Aims and Objectives
The aim and objective of the Antiseptics Working Group is to explore and promote prevention and treatment of infection by use of Antiseptics. This will be achieved by fostering and promoting clinical studies investigating the potential of antiseptics in an international network of collaborative sites.
In view of the increasing bacterial resistance towards antibiotics, antiseptics may be an alternative for both, prevention and treatment of infection. Antibiotics often have a single or a limited number of pharmacological targets in microorganisms. Antiseptics generally have multiple targets such as membrane damage, cytoplasm coagulation, general cell inactivation depending on the concentration of the antiseptic. Antiseptics have a long history of use, with early examples being Semmelweis’ chlorinated lime solutions (1848) and Lister's carbolic spray in 1869.
Today’s antiseptic armamentarium embraces a surprisingly wide range of substances including chlorhexidine, polyhexamethylene biguanide (polyhexanide), povidone-iodine, Octendine-dihydrochloride, triclosan, hypochlorite, silver, honey, vinegar, and many others. The clinical use of antiseptics could have an enormous impact on medical practice, especially given the current pressure for clinicians to reduce their use of antibiotics.